Can a Acer Predator with a GTX645 4gb of cram run Minecraft with shaders?

Yes, easily on the highest in-game settings. That graphics card is actually faster than a GTX 650… Go figure. It's considerably faster than the graphics requirement for Minecraft, so it'll have no problems with that game.
http://gpuboss.com/gpus/GeForce-GTX-650-vs-GeForce-GTX-645